Cellular and molecular biology of Alzheimer's disease and animal models

S. S. Sisodia, L. J. Martin, L. C. Walker, D. R. Borchelt, D. L. Price

Research output: Contribution to journalReview articlepeer-review

Abstract

The most common severe disabilities of the elderly is the impairment of cognitive and memory processes that occur in Alzheimer's disease (AD). The principal histopathologic hallmarks of AD are the formation of neurofibrillary tangles involving specific populations of neurons and the extracellular deposition of the β-amyloid (Aβ) in the parenchyma and around the cerebral blood vessels. This review briefly describes the abnormalities of neurons and examines in detail the biology of the amyloid precursor protein and Aβ as studied in vitro and in vivo in animal models.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalNeuroimaging Clinics of North America
Volume5
Issue number1
StatePublished - 1995

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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