Cellular and Molecular Aspects of Dyssynchrony and Resynchronization

Jonathan A. Kirk, David A Kass

Research output: Contribution to journalReview article

Abstract

Dyssynchronous contraction of the ventricle significantly worsens morbidity and mortality in patients with heart failure (HF). Approximately one-third of patients with HF have cardiac dyssynchrony and are candidates for cardiac resynchronization therapy (CRT). The initial understanding of dyssynchrony and CRT was in terms of global mechanics and hemodynamics, but lack of clinical benefit in a sizable subgroup of recipients who appear otherwise appropriate has challenged this paradigm. This article reviews current understanding of these cellular and subcellular mechanisms, arguing that these aspects are key to improving CRT use, as well as translating its benefits to a wider HF population.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalHeart Failure Clinics
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Animal models
  • Cardiac resynchronization therapy
  • Dyssynchrony
  • Myocyte
  • Myofilament

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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