TY - JOUR
T1 - Cells infected with a cell-associated subacute sclerosing panencephalitis virus do not express M protein
AU - Machamer, Carolyn E.
AU - Hayes, Edward C.Z.
AU - Zweerink, Hans J.
N1 - Funding Information:
This work was supported by Public Health Service (PHS) Research Grant AI 10132 from the National Institute of Allergy and Infectious Diseases. H.J.Z. was a recipient of PHS Research Career Development Award NS 0086 from the National Institute of Neurological Diseases and Stroke. E C. H. was sup ported by PHS Grant T32-CA-0911 from the National Cancer Institute, and C.E.M. by PHS Grant T32-GM-07184 from the National Institute of General Medical Sciences.
PY - 1981/1/30
Y1 - 1981/1/30
N2 - Using immunoprecipitation techniques, we have analyzed measles-specific antibodies in the cerebrospinal fluids (CSF) as well as in sera from patients with subacute sclerosing panencephalitis (SSPE). We confirm previous reports that SSPE sera contain a relative lack of M protein-specific antibodies, and report that CSF also have antibodies specific for all measles polypeptides except the M protein. We have also found that Vero cells infected with one of the SSPE viruses used in this study, the cell-associated IP-3 strain, completely lack expression of detectable M protein. Thus, the lack of M protein-specific antibody in the CSF of SSPE patients may be the result of a lack of expression of this polypeptide in the cells of the central nervous system.
AB - Using immunoprecipitation techniques, we have analyzed measles-specific antibodies in the cerebrospinal fluids (CSF) as well as in sera from patients with subacute sclerosing panencephalitis (SSPE). We confirm previous reports that SSPE sera contain a relative lack of M protein-specific antibodies, and report that CSF also have antibodies specific for all measles polypeptides except the M protein. We have also found that Vero cells infected with one of the SSPE viruses used in this study, the cell-associated IP-3 strain, completely lack expression of detectable M protein. Thus, the lack of M protein-specific antibody in the CSF of SSPE patients may be the result of a lack of expression of this polypeptide in the cells of the central nervous system.
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U2 - 10.1016/0042-6822(81)90460-8
DO - 10.1016/0042-6822(81)90460-8
M3 - Article
C2 - 7467128
AN - SCOPUS:0019377091
SN - 0042-6822
VL - 108
SP - 515
EP - 520
JO - Virology
JF - Virology
IS - 2
ER -