Cells infected with a cell-associated subacute sclerosing panencephalitis virus do not express M protein

Carolyn E. Machamer, Edward C.Z. Hayes, Hans J. Zweerink

Research output: Contribution to journalArticle

Abstract

Using immunoprecipitation techniques, we have analyzed measles-specific antibodies in the cerebrospinal fluids (CSF) as well as in sera from patients with subacute sclerosing panencephalitis (SSPE). We confirm previous reports that SSPE sera contain a relative lack of M protein-specific antibodies, and report that CSF also have antibodies specific for all measles polypeptides except the M protein. We have also found that Vero cells infected with one of the SSPE viruses used in this study, the cell-associated IP-3 strain, completely lack expression of detectable M protein. Thus, the lack of M protein-specific antibody in the CSF of SSPE patients may be the result of a lack of expression of this polypeptide in the cells of the central nervous system.

Original languageEnglish (US)
Pages (from-to)515-520
Number of pages6
JournalVirology
Volume108
Issue number2
DOIs
StatePublished - Jan 30 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Virology

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