Cell tracking in cardiac repair: What to image and how to image

Alessandro Ruggiero, Daniel L J Thorek, Jamal Guenoun, Gabriel P. Krestin, Monique R. Bernsen

Research output: Contribution to journalArticle

Abstract

Stem cell therapies hold the great promise and interest for cardiac regeneration among scientists, clinicians and patients. However, advancement and distillation of a standard treatment regimen are not yet finalised. Into this breach step recent developments in the imaging biosciences. Thus far, these technical and protocol refinements have played a critical role not only in the evaluation of the recovery of cardiac function but also in providing important insights into the mechanism of action of stem cells. Molecular imaging, in its many forms, has rapidly become a necessary tool for the validation and optimisation of stem cell engrafting strategies in preclinical studies. These include a suite of radionuclide, magnetic resonance and optical imaging strategies to evaluate non-invasively the fate of transplanted cells. In this review, we highlight the state-of-the-art of the various imaging techniques for cardiac stem cell presenting the strengths and limitations of each approach, with a particular focus on clinical applicability.

Original languageEnglish (US)
Pages (from-to)189-204
Number of pages16
JournalEuropean Radiology
Volume22
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Cell Tracking
Stem Cells
Cardiac Imaging Techniques
Molecular Imaging
Distillation
Optical Imaging
Recovery of Function
Cell- and Tissue-Based Therapy
Radioisotopes
Regeneration
Magnetic Resonance Imaging

Keywords

  • Cell tracking
  • Heart failure
  • Molecular imaging
  • Myocardial infarction
  • Stem cells

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ruggiero, A., Thorek, D. L. J., Guenoun, J., Krestin, G. P., & Bernsen, M. R. (2012). Cell tracking in cardiac repair: What to image and how to image. European Radiology, 22(1), 189-204. https://doi.org/10.1007/s00330-011-2190-7

Cell tracking in cardiac repair : What to image and how to image. / Ruggiero, Alessandro; Thorek, Daniel L J; Guenoun, Jamal; Krestin, Gabriel P.; Bernsen, Monique R.

In: European Radiology, Vol. 22, No. 1, 01.2012, p. 189-204.

Research output: Contribution to journalArticle

Ruggiero, A, Thorek, DLJ, Guenoun, J, Krestin, GP & Bernsen, MR 2012, 'Cell tracking in cardiac repair: What to image and how to image', European Radiology, vol. 22, no. 1, pp. 189-204. https://doi.org/10.1007/s00330-011-2190-7
Ruggiero A, Thorek DLJ, Guenoun J, Krestin GP, Bernsen MR. Cell tracking in cardiac repair: What to image and how to image. European Radiology. 2012 Jan;22(1):189-204. https://doi.org/10.1007/s00330-011-2190-7
Ruggiero, Alessandro ; Thorek, Daniel L J ; Guenoun, Jamal ; Krestin, Gabriel P. ; Bernsen, Monique R. / Cell tracking in cardiac repair : What to image and how to image. In: European Radiology. 2012 ; Vol. 22, No. 1. pp. 189-204.
@article{3d1204aff03a48b9a3698e0be982a872,
title = "Cell tracking in cardiac repair: What to image and how to image",
abstract = "Stem cell therapies hold the great promise and interest for cardiac regeneration among scientists, clinicians and patients. However, advancement and distillation of a standard treatment regimen are not yet finalised. Into this breach step recent developments in the imaging biosciences. Thus far, these technical and protocol refinements have played a critical role not only in the evaluation of the recovery of cardiac function but also in providing important insights into the mechanism of action of stem cells. Molecular imaging, in its many forms, has rapidly become a necessary tool for the validation and optimisation of stem cell engrafting strategies in preclinical studies. These include a suite of radionuclide, magnetic resonance and optical imaging strategies to evaluate non-invasively the fate of transplanted cells. In this review, we highlight the state-of-the-art of the various imaging techniques for cardiac stem cell presenting the strengths and limitations of each approach, with a particular focus on clinical applicability.",
keywords = "Cell tracking, Heart failure, Molecular imaging, Myocardial infarction, Stem cells",
author = "Alessandro Ruggiero and Thorek, {Daniel L J} and Jamal Guenoun and Krestin, {Gabriel P.} and Bernsen, {Monique R.}",
year = "2012",
month = "1",
doi = "10.1007/s00330-011-2190-7",
language = "English (US)",
volume = "22",
pages = "189--204",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Cell tracking in cardiac repair

T2 - What to image and how to image

AU - Ruggiero, Alessandro

AU - Thorek, Daniel L J

AU - Guenoun, Jamal

AU - Krestin, Gabriel P.

AU - Bernsen, Monique R.

PY - 2012/1

Y1 - 2012/1

N2 - Stem cell therapies hold the great promise and interest for cardiac regeneration among scientists, clinicians and patients. However, advancement and distillation of a standard treatment regimen are not yet finalised. Into this breach step recent developments in the imaging biosciences. Thus far, these technical and protocol refinements have played a critical role not only in the evaluation of the recovery of cardiac function but also in providing important insights into the mechanism of action of stem cells. Molecular imaging, in its many forms, has rapidly become a necessary tool for the validation and optimisation of stem cell engrafting strategies in preclinical studies. These include a suite of radionuclide, magnetic resonance and optical imaging strategies to evaluate non-invasively the fate of transplanted cells. In this review, we highlight the state-of-the-art of the various imaging techniques for cardiac stem cell presenting the strengths and limitations of each approach, with a particular focus on clinical applicability.

AB - Stem cell therapies hold the great promise and interest for cardiac regeneration among scientists, clinicians and patients. However, advancement and distillation of a standard treatment regimen are not yet finalised. Into this breach step recent developments in the imaging biosciences. Thus far, these technical and protocol refinements have played a critical role not only in the evaluation of the recovery of cardiac function but also in providing important insights into the mechanism of action of stem cells. Molecular imaging, in its many forms, has rapidly become a necessary tool for the validation and optimisation of stem cell engrafting strategies in preclinical studies. These include a suite of radionuclide, magnetic resonance and optical imaging strategies to evaluate non-invasively the fate of transplanted cells. In this review, we highlight the state-of-the-art of the various imaging techniques for cardiac stem cell presenting the strengths and limitations of each approach, with a particular focus on clinical applicability.

KW - Cell tracking

KW - Heart failure

KW - Molecular imaging

KW - Myocardial infarction

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=84857062905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857062905&partnerID=8YFLogxK

U2 - 10.1007/s00330-011-2190-7

DO - 10.1007/s00330-011-2190-7

M3 - Article

C2 - 21735069

AN - SCOPUS:84857062905

VL - 22

SP - 189

EP - 204

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 1

ER -