Abstract
MUC1 is a tumor-associated antigen that is overexpressed in invasive ductal carcinomas of the pancreas (PC). MUC1-specific cytotoxic T lymphocytes (CTLs) recognize MUC1 molecules in an HLA-unrestricted manner. We have reported the efficacy of adoptive immunotherapy (AIT) with CTLs stimulated by autologous pancreatic tumors and vaccination with a variety of peptides. We also have reported the use of AIT with CTLs (MUC1-CTLs)stimulated by an MUC1-expressing human pancreatic cancer cell line, YPK-1. AIT with MUC1-CTLs for unresectable pancreatic cancer did not improve survival, although no patient without liver metastasis developed liver metastasis during the study. To overcome these limitations, we developed an AIT using a combination of MUC1-CTLs and dendritic cells (DCs) pulsed with MUC1-peptide. This AIT showed good results. In our next study, we are planning AIT with MUC1-CTLs and DCs transfected with MUC1-mRNA for unresectable PC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-110 |
| Number of pages | 6 |
| Journal | Biotherapy |
| Volume | 24 |
| Issue number | 2 |
| State | Published - Mar 2010 |
| Externally published | Yes |
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Keywords
- Bectroporation
- Immunotherapv
- MUC1
- Pancreatic cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Cell therapy for pancreatic cancer : MUC1-specific cytotoxic T cell and MUC1 mRNA introduction dendritic cell therapy. / Maeda, Yoshinari; Hazama, Shoichi; Yoshida, Shin; Maeda, Kazunari; Sonoda, Yuka; Yanai, Yuko; Yoshimura, Kiyoshi; Iida, Michihisa; Suzuki, Nobuaki; Ueno, Tomio; Yoshino, Shigefumi; Oka, Masaaki.
In: Biotherapy, Vol. 24, No. 2, 03.2010, p. 105-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell therapy for pancreatic cancer
T2 - MUC1-specific cytotoxic T cell and MUC1 mRNA introduction dendritic cell therapy
AU - Maeda, Yoshinari
AU - Hazama, Shoichi
AU - Yoshida, Shin
AU - Maeda, Kazunari
AU - Sonoda, Yuka
AU - Yanai, Yuko
AU - Yoshimura, Kiyoshi
AU - Iida, Michihisa
AU - Suzuki, Nobuaki
AU - Ueno, Tomio
AU - Yoshino, Shigefumi
AU - Oka, Masaaki
PY - 2010/3
Y1 - 2010/3
N2 - MUC1 is a tumor-associated antigen that is overexpressed in invasive ductal carcinomas of the pancreas (PC). MUC1-specific cytotoxic T lymphocytes (CTLs) recognize MUC1 molecules in an HLA-unrestricted manner. We have reported the efficacy of adoptive immunotherapy (AIT) with CTLs stimulated by autologous pancreatic tumors and vaccination with a variety of peptides. We also have reported the use of AIT with CTLs (MUC1-CTLs)stimulated by an MUC1-expressing human pancreatic cancer cell line, YPK-1. AIT with MUC1-CTLs for unresectable pancreatic cancer did not improve survival, although no patient without liver metastasis developed liver metastasis during the study. To overcome these limitations, we developed an AIT using a combination of MUC1-CTLs and dendritic cells (DCs) pulsed with MUC1-peptide. This AIT showed good results. In our next study, we are planning AIT with MUC1-CTLs and DCs transfected with MUC1-mRNA for unresectable PC.
AB - MUC1 is a tumor-associated antigen that is overexpressed in invasive ductal carcinomas of the pancreas (PC). MUC1-specific cytotoxic T lymphocytes (CTLs) recognize MUC1 molecules in an HLA-unrestricted manner. We have reported the efficacy of adoptive immunotherapy (AIT) with CTLs stimulated by autologous pancreatic tumors and vaccination with a variety of peptides. We also have reported the use of AIT with CTLs (MUC1-CTLs)stimulated by an MUC1-expressing human pancreatic cancer cell line, YPK-1. AIT with MUC1-CTLs for unresectable pancreatic cancer did not improve survival, although no patient without liver metastasis developed liver metastasis during the study. To overcome these limitations, we developed an AIT using a combination of MUC1-CTLs and dendritic cells (DCs) pulsed with MUC1-peptide. This AIT showed good results. In our next study, we are planning AIT with MUC1-CTLs and DCs transfected with MUC1-mRNA for unresectable PC.
KW - Bectroporation
KW - Immunotherapv
KW - MUC1
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=77951541226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951541226&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77951541226
VL - 24
SP - 105
EP - 110
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 2
ER -