Abstract
MUC1 is a tumor-associated antigen that is overexpressed in invasive ductal carcinomas of the pancreas (PC). MUC1-specific cytotoxic T lymphocytes (CTLs) recognize MUC1 molecules in an HLA-unrestricted manner. We have reported the efficacy of adoptive immunotherapy (AIT) with CTLs stimulated by autologous pancreatic tumors and vaccination with a variety of peptides. We also have reported the use of AIT with CTLs (MUC1-CTLs)stimulated by an MUC1-expressing human pancreatic cancer cell line, YPK-1. AIT with MUC1-CTLs for unresectable pancreatic cancer did not improve survival, although no patient without liver metastasis developed liver metastasis during the study. To overcome these limitations, we developed an AIT using a combination of MUC1-CTLs and dendritic cells (DCs) pulsed with MUC1-peptide. This AIT showed good results. In our next study, we are planning AIT with MUC1-CTLs and DCs transfected with MUC1-mRNA for unresectable PC.
Original language | English (US) |
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Pages (from-to) | 105-110 |
Number of pages | 6 |
Journal | Biotherapy |
Volume | 24 |
Issue number | 2 |
State | Published - Mar 2010 |
Externally published | Yes |
Keywords
- Bectroporation
- Immunotherapv
- MUC1
- Pancreatic cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology