Abstract
Myocardial infarction results in loss of cardiomyocytes, scar formation, ventricular remodelling, and eventually heart failure. In recent years, cell therapy has emerged as a potential new strategy for patients with ischaemic heart disease. This includes embryonic and bone marrow derived stem cells. Recent clinical studies showed ostensibly conflicting results of intracoronary infusion of autologous bone marrow derived stem cells in patients with acute or chronic myocardial infarction. Anyway, these results have stimulated additional clinical and pre-clinical studies to further enhance the beneficial effects of stem cell therapy. Recently, the existence of cardiac stem cells that reside in the heart itself was demonstrated. Their discovery has sparked intense hope for myocardial regeneration with cells that are obtained from the heart itself and are thereby inherently programmed to reconstitute cardiac tissue. These cells can be detected by several surface markers (e.g. c-kit, Sca-1, MDR1, Isl-1). Both in vitro and in vivo differentiation into cardiomyocytes, endothelial cells and vascular smooth muscle cells has been demonstrated, and animal studies showed promising results on improvement of left ventricular function. This review will discuss current views regarding the feasibility of cardiac repair, and focus on the potential role of the resident cardiac stem and progenitor cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-207 |
| Number of pages | 9 |
| Journal | Netherlands Heart Journal |
| Volume | 17 |
| Issue number | 5 |
| State | Published - May 2009 |
| Externally published | Yes |
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Keywords
- Cardiac stem cell
- Ischaemic heart disease
- Regeneration
- Stem cell therapy
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Cell therapy for ischaemic heart disease : Focus on the role of resident cardiac stem cells. / Chamuleau, S. A J; Vrijsen, K. R.; Rokosh, D. G.; Tang, X. L.; Piek, J. J.; Bolli, R.
In: Netherlands Heart Journal, Vol. 17, No. 5, 05.2009, p. 199-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell therapy for ischaemic heart disease
T2 - Focus on the role of resident cardiac stem cells
AU - Chamuleau, S. A J
AU - Vrijsen, K. R.
AU - Rokosh, D. G.
AU - Tang, X. L.
AU - Piek, J. J.
AU - Bolli, R.
PY - 2009/5
Y1 - 2009/5
N2 - Myocardial infarction results in loss of cardiomyocytes, scar formation, ventricular remodelling, and eventually heart failure. In recent years, cell therapy has emerged as a potential new strategy for patients with ischaemic heart disease. This includes embryonic and bone marrow derived stem cells. Recent clinical studies showed ostensibly conflicting results of intracoronary infusion of autologous bone marrow derived stem cells in patients with acute or chronic myocardial infarction. Anyway, these results have stimulated additional clinical and pre-clinical studies to further enhance the beneficial effects of stem cell therapy. Recently, the existence of cardiac stem cells that reside in the heart itself was demonstrated. Their discovery has sparked intense hope for myocardial regeneration with cells that are obtained from the heart itself and are thereby inherently programmed to reconstitute cardiac tissue. These cells can be detected by several surface markers (e.g. c-kit, Sca-1, MDR1, Isl-1). Both in vitro and in vivo differentiation into cardiomyocytes, endothelial cells and vascular smooth muscle cells has been demonstrated, and animal studies showed promising results on improvement of left ventricular function. This review will discuss current views regarding the feasibility of cardiac repair, and focus on the potential role of the resident cardiac stem and progenitor cells.
AB - Myocardial infarction results in loss of cardiomyocytes, scar formation, ventricular remodelling, and eventually heart failure. In recent years, cell therapy has emerged as a potential new strategy for patients with ischaemic heart disease. This includes embryonic and bone marrow derived stem cells. Recent clinical studies showed ostensibly conflicting results of intracoronary infusion of autologous bone marrow derived stem cells in patients with acute or chronic myocardial infarction. Anyway, these results have stimulated additional clinical and pre-clinical studies to further enhance the beneficial effects of stem cell therapy. Recently, the existence of cardiac stem cells that reside in the heart itself was demonstrated. Their discovery has sparked intense hope for myocardial regeneration with cells that are obtained from the heart itself and are thereby inherently programmed to reconstitute cardiac tissue. These cells can be detected by several surface markers (e.g. c-kit, Sca-1, MDR1, Isl-1). Both in vitro and in vivo differentiation into cardiomyocytes, endothelial cells and vascular smooth muscle cells has been demonstrated, and animal studies showed promising results on improvement of left ventricular function. This review will discuss current views regarding the feasibility of cardiac repair, and focus on the potential role of the resident cardiac stem and progenitor cells.
KW - Cardiac stem cell
KW - Ischaemic heart disease
KW - Regeneration
KW - Stem cell therapy
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M3 - Article
C2 - 19484156
AN - SCOPUS:70349293932
VL - 17
SP - 199
EP - 207
JO - Netherlands Heart Journal
JF - Netherlands Heart Journal
SN - 1568-5888
IS - 5
ER -