Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model

Yuwen Zhu, Sheng Yao, Lieping Chen

Research output: Contribution to journalArticle

Abstract

A large numbers of cell surface signaling molecules (CSSMs) have been molecularly identified and functionally characterized in recent years and, via these studies, our knowledge in the control of immune response has increased exponentially. Two major lines of evidence emerge. First, the majority of immune cells rely on one or few CSSMs to deliver a primary triggering signal to sense their environment, leading to initiation of an immune response. Second, both costimulatory CSSMs that promote the response, and coinhibitory CSSMs that inhibit the response, are required to control direction and magnitude of a given immune response. With such tight feedback, immune responses are tuned and returned to baseline. These findings extend well beyond our previous observation in the requirement for lymphocyte activation and argue a revisit of the traditional " two-signal model" for activation and tolerance of lymphocytes. Here we propose a " tide" model to accommodate and interpret current experimental findings.

Original languageEnglish (US)
Pages (from-to)466-478
Number of pages13
JournalImmunity
Volume34
Issue number4
DOIs
StatePublished - Apr 22 2011
Externally publishedYes

Fingerprint

Lymphocyte Activation
Cell Count
Observation
Direction compound

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Cell Surface Signaling Molecules in the Control of Immune Responses : A Tide Model. / Zhu, Yuwen; Yao, Sheng; Chen, Lieping.

In: Immunity, Vol. 34, No. 4, 22.04.2011, p. 466-478.

Research output: Contribution to journalArticle

Zhu, Yuwen ; Yao, Sheng ; Chen, Lieping. / Cell Surface Signaling Molecules in the Control of Immune Responses : A Tide Model. In: Immunity. 2011 ; Vol. 34, No. 4. pp. 466-478.
@article{cbc8302f6c3543c2814575beaeb53600,
title = "Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model",
abstract = "A large numbers of cell surface signaling molecules (CSSMs) have been molecularly identified and functionally characterized in recent years and, via these studies, our knowledge in the control of immune response has increased exponentially. Two major lines of evidence emerge. First, the majority of immune cells rely on one or few CSSMs to deliver a primary triggering signal to sense their environment, leading to initiation of an immune response. Second, both costimulatory CSSMs that promote the response, and coinhibitory CSSMs that inhibit the response, are required to control direction and magnitude of a given immune response. With such tight feedback, immune responses are tuned and returned to baseline. These findings extend well beyond our previous observation in the requirement for lymphocyte activation and argue a revisit of the traditional {"} two-signal model{"} for activation and tolerance of lymphocytes. Here we propose a {"} tide{"} model to accommodate and interpret current experimental findings.",
author = "Yuwen Zhu and Sheng Yao and Lieping Chen",
year = "2011",
month = "4",
day = "22",
doi = "10.1016/j.immuni.2011.04.008",
language = "English (US)",
volume = "34",
pages = "466--478",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Cell Surface Signaling Molecules in the Control of Immune Responses

T2 - A Tide Model

AU - Zhu, Yuwen

AU - Yao, Sheng

AU - Chen, Lieping

PY - 2011/4/22

Y1 - 2011/4/22

N2 - A large numbers of cell surface signaling molecules (CSSMs) have been molecularly identified and functionally characterized in recent years and, via these studies, our knowledge in the control of immune response has increased exponentially. Two major lines of evidence emerge. First, the majority of immune cells rely on one or few CSSMs to deliver a primary triggering signal to sense their environment, leading to initiation of an immune response. Second, both costimulatory CSSMs that promote the response, and coinhibitory CSSMs that inhibit the response, are required to control direction and magnitude of a given immune response. With such tight feedback, immune responses are tuned and returned to baseline. These findings extend well beyond our previous observation in the requirement for lymphocyte activation and argue a revisit of the traditional " two-signal model" for activation and tolerance of lymphocytes. Here we propose a " tide" model to accommodate and interpret current experimental findings.

AB - A large numbers of cell surface signaling molecules (CSSMs) have been molecularly identified and functionally characterized in recent years and, via these studies, our knowledge in the control of immune response has increased exponentially. Two major lines of evidence emerge. First, the majority of immune cells rely on one or few CSSMs to deliver a primary triggering signal to sense their environment, leading to initiation of an immune response. Second, both costimulatory CSSMs that promote the response, and coinhibitory CSSMs that inhibit the response, are required to control direction and magnitude of a given immune response. With such tight feedback, immune responses are tuned and returned to baseline. These findings extend well beyond our previous observation in the requirement for lymphocyte activation and argue a revisit of the traditional " two-signal model" for activation and tolerance of lymphocytes. Here we propose a " tide" model to accommodate and interpret current experimental findings.

UR - http://www.scopus.com/inward/record.url?scp=79954571318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954571318&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2011.04.008

DO - 10.1016/j.immuni.2011.04.008

M3 - Article

C2 - 21511182

AN - SCOPUS:79954571318

VL - 34

SP - 466

EP - 478

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 4

ER -