Cell surface antigens and function of monocytes and a monocyte-like cell line before and after infection with HIV

Dean L. Mann, Suzanne Gartner, Frances LeSane, William A. Blattner, Mikulas Popovic

Research output: Contribution to journalArticlepeer-review

Abstract

The human immunodeficiency virus (HIV-1) preferentially infects cells that express the CD4 molecule, including monocytes and cells of the monocyte lineage. The monocyte-like cell line U937 and monocytes isolated from peripheral blood lymphocytes (PBL) were infected with HIV-1. Cell surface antigen expression was determined in infected and noninfected cells as was the ability to stimulate in mixed lymphocyte reaction. The CD4 antigen decreased in infected cells U937 and PBL monocytes. MHC class II antigens HLA-DR, HLA-DQ, and HLA-DP increased in HIV-1 infected U937 cells. In infected PBL-derived monocytes, HLA-DR increased, HLA-DQ decreased, and HLA-DP was unchanged. Infected U937 and PBL monocytes were capable of stimulating allogeneic lymphocytes, thus demonstrating retention of the alloantigen presentation function of HIV-1-infected monocytes.

Original languageEnglish (US)
Pages (from-to)174-183
Number of pages10
JournalClinical Immunology and Immunopathology
Volume54
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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