Cell size and capillary supply of the hypertensive rat heart: quantitative study

K. Rakusan; P. W. Hrdina; Z. Turek; E. G. Lakatta; H. A. Spurgeon; G. D. Wolford

doi:10.1007/BF01908138

Cell size and capillary supply of the hypertensive rat heart: quantitative study

K. Rakusan, P. W. Hrdina, Z. Turek, E. G. Lakatta, H. A. Spurgeon, G. D. Wolford

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 months, but was 15 months and became even more so by 23 months. This increase could be attributed to hypertrophy of the individual cardiac muscle cells and therefore, the estimated total number of myocytes per left ventricle was essentially the same in all experimental groups. Various indices of the myocardial capillary supply were also investigated. Cardiac hypertrophy in older hypertensive rats was characterized by greater and more variable intercapillary spacing, which may have importance in myocardial oxygen supply.

Original language	English (US)
Pages (from-to)	389-395
Number of pages	7
Journal	Basic Research in Cardiology
Volume	79
Issue number	4
DOIs	https://doi.org/10.1007/BF01908138
State	Published - Jul 1984
Externally published	Yes

Keywords

cardiac aging
cardiac hypertrophy
diffusion distance
spontaneous hypertension
terminal vascular bed

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1007/BF01908138

Cite this

@article{adf5ee986772473d9f065dee1ea72ecd,

title = "Cell size and capillary supply of the hypertensive rat heart: quantitative study",

abstract = "Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 months, but was 15 months and became even more so by 23 months. This increase could be attributed to hypertrophy of the individual cardiac muscle cells and therefore, the estimated total number of myocytes per left ventricle was essentially the same in all experimental groups. Various indices of the myocardial capillary supply were also investigated. Cardiac hypertrophy in older hypertensive rats was characterized by greater and more variable intercapillary spacing, which may have importance in myocardial oxygen supply.",

keywords = "cardiac aging, cardiac hypertrophy, diffusion distance, spontaneous hypertension, terminal vascular bed",

author = "K. Rakusan and Hrdina, {P. W.} and Z. Turek and Lakatta, {E. G.} and Spurgeon, {H. A.} and Wolford, {G. D.}",

year = "1984",

month = jul,

doi = "10.1007/BF01908138",

language = "English (US)",

volume = "79",

pages = "389--395",

journal = "Basic Research in Cardiology",

issn = "0300-8428",

publisher = "D. Steinkopff-Verlag",

number = "4",

}

TY - JOUR

T1 - Cell size and capillary supply of the hypertensive rat heart

T2 - quantitative study

AU - Rakusan, K.

AU - Hrdina, P. W.

AU - Turek, Z.

AU - Lakatta, E. G.

AU - Spurgeon, H. A.

AU - Wolford, G. D.

PY - 1984/7

Y1 - 1984/7

N2 - Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 months, but was 15 months and became even more so by 23 months. This increase could be attributed to hypertrophy of the individual cardiac muscle cells and therefore, the estimated total number of myocytes per left ventricle was essentially the same in all experimental groups. Various indices of the myocardial capillary supply were also investigated. Cardiac hypertrophy in older hypertensive rats was characterized by greater and more variable intercapillary spacing, which may have importance in myocardial oxygen supply.

AB - Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 months, but was 15 months and became even more so by 23 months. This increase could be attributed to hypertrophy of the individual cardiac muscle cells and therefore, the estimated total number of myocytes per left ventricle was essentially the same in all experimental groups. Various indices of the myocardial capillary supply were also investigated. Cardiac hypertrophy in older hypertensive rats was characterized by greater and more variable intercapillary spacing, which may have importance in myocardial oxygen supply.

KW - cardiac aging

KW - cardiac hypertrophy

KW - diffusion distance

KW - spontaneous hypertension

KW - terminal vascular bed

UR - http://www.scopus.com/inward/record.url?scp=0021162569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021162569&partnerID=8YFLogxK

U2 - 10.1007/BF01908138

DO - 10.1007/BF01908138

M3 - Article

C2 - 6237640

AN - SCOPUS:0021162569

SN - 0300-8428

VL - 79

SP - 389

EP - 395

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 4

ER -

Cell size and capillary supply of the hypertensive rat heart: quantitative study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this