Cell signaling and neuronal death

Makoto R. Hara, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

The past few decades have revealed that cell death can be precisely programmed with two principal forms, apoptosis and necrosis. Besides pathophysiological alterations, physiologic processes, such as the pruning of neurons during normal development and the involution of the thymus, involve apoptosis. This review focuses on the role of inter- and intracellular signaling systems in cell death, especially in the nervous system. Among neurotransmitters, glutamate and nitric oxide have been most extensively characterized and contribute to cell death in excitotoxic damage, especially in stroke and possibly in neurodegenerative diseases. Within cells, calcium, the most prominent of all intracellular messengers, mediates diverse forms of cell death with actions modulated by many proteins, including IP3 receptors, calcineurin, calpain, and cytochrome c.

Original languageEnglish (US)
Pages (from-to)117-141
Number of pages25
JournalAnnual Review of Pharmacology and Toxicology
Volume47
DOIs
StatePublished - 2007

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Cell signaling
Cell death
Cell Death
Neurodegenerative diseases
Apoptosis
Inositol 1,4,5-Trisphosphate Receptors
Thymus
Calpain
Calcineurin
Neurology
Cytochromes c
Neurodegenerative Diseases
Thymus Gland
Nervous System
Neurons
Neurotransmitter Agents
Glutamic Acid
Nitric Oxide
Necrosis
Stroke

Keywords

  • Apoptosis
  • Calcium
  • Glutamate
  • Nitric oxide
  • S-nitrosylation

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Cell signaling and neuronal death. / Hara, Makoto R.; Snyder, Solomon H.

In: Annual Review of Pharmacology and Toxicology, Vol. 47, 2007, p. 117-141.

Research output: Contribution to journalArticle

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