Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters

Deendayal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang

Research output: Contribution to journalArticle

Abstract

Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W 5R 4K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).

Original languageEnglish (US)
Pages (from-to)9633-9637
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number41
DOIs
StatePublished - Oct 4 2011
Externally publishedYes

Keywords

  • amphiphiles
  • drug delivery
  • endocytosis
  • nuclear targeting
  • peptides

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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