Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters

Deendayal Mandal; Amir Nasrolahi Shirazi; Keykavous Parang

doi:10.1002/anie.201102572

Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters

Deendayal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W ₅R ₄K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).

Original language	English (US)
Pages (from-to)	9633-9637
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	41
DOIs	https://doi.org/10.1002/anie.201102572
State	Published - Oct 4 2011
Externally published	Yes

Keywords

amphiphiles
drug delivery
endocytosis
nuclear targeting
peptides

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.201102572

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title = "Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters",

abstract = "Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W 5R 4K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).",

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author = "Deendayal Mandal and {Nasrolahi Shirazi}, Amir and Keykavous Parang",

year = "2011",

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doi = "10.1002/anie.201102572",

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AU - Mandal, Deendayal

AU - Nasrolahi Shirazi, Amir

AU - Parang, Keykavous

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Y1 - 2011/10/4

N2 - Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W 5R 4K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).

AB - Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W 5R 4K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture).

KW - amphiphiles

KW - drug delivery

KW - endocytosis

KW - nuclear targeting

KW - peptides

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M3 - Article

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ER -

Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters

Abstract

Keywords

ASJC Scopus subject areas

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