Cell Microencapsulation for Tissue Engineering and Regenerative Medicine

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell encapsulation was originally envisioned decades ago as a way to protect cells from the host's immune system to facilitate transplantation therapies and now serves additional roles such as localization of cells to a desired site in the body. In recent years, the pace of progress has increased as novel techniques for fabricating microcapsules have dovetailed with a growing number of biocompatible natural and synthetic polymers suitable for supporting cell growth, proliferation, and secretion of growth factors. This chapter provides an overview of general design parameters important for encapsulation, which include the size of the capsule and permeability to allow or exclude the passage of nutrients, small molecules, and larger proteins, and then discusses various biocompatible materials now used for cell encapsulation. Finally, an overview of emerging therapies-several of which are already in clinical trials-is given including those designed for the treatment of diabetes, cancer, neurological disorders, and liver disease.

Original languageEnglish (US)
Title of host publicationMicro-and Nanoengineering of the Cell Surface
PublisherElsevier Inc.
Pages215-239
Number of pages25
ISBN (Electronic)9781455731558
ISBN (Print)9781455731466
DOIs
StatePublished - Jun 6 2014

Keywords

  • Biomaterials
  • Cell microencapsulation
  • Cell-based transplantation therapies
  • Hydrogels
  • Microencapsulation techniques

ASJC Scopus subject areas

  • Engineering(all)

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