Cell-mediated immunity in autoimmune thyroid disease

C. Lynne Burek, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

The initiation of an autoimmune response requires the establishment of an appropriate microenvironment. This, in turn, involves several requirements, including antigen expression on the membrane surface of the target cells, class II antigen expression on the antigen-presenting cell or target cells, a relative systemic or local increase in the helper/inducer subset of T cells, and/or a relative decrease in the suppressor subset of T cells. All of these conditions have been described in the thyroid gland. Apropriate cellular interactions results in the appearance of activated T cells and the generation of cytotoxic T cells. The pathologic alterations may be produced by the local production of antibody and subsequent formation of immune complexes, by direct lymphocyte damage, or by lymphokine production. Autoimmune thyroid disease remains, to our minds, the most instructive paradigm of the organspecific autoimmune endocrinopathies.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalHuman pathology
Volume17
Issue number3
DOIs
StatePublished - Mar 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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