Cell-mediated immune deficiency and malnutrition are independent risk factors for persistent diarrhea in Bangladeshi children

A. H. Baqui, R. B. Sack, R. E. Black, H. R. Chowdhury, M. Yunus, A. K. Siddique

Research output: Contribution to journalArticle


A community-based longitudinal study was carried out at Matlab, Bangladesh, to investigate the magnitude of the problem of persistent diarrhea; 705 children aged < 5 y were followed, yielding 7300 child-months of observation in 1 y. Morbidity data were collected every fourth day by home visit, anthropometric status was determined monthly, and cell-mediated immune status was assessed every 3 mo. The incidence of persistent diarrhea was 34 episodes per 100 child-years; rates were highest in infancy and declined through the remainder of childhood. In a logistic-regression model, weight- for-height status and immune status were significant predictors of persistent diarrhea. Compared with those at zero Z score, children with weight-for- height at -2 would have a 3.5 times increased risk of persistent diarrhea. Compared with immunocompetent children, immunodeficient children had about twice the risk of developing persistent diarrhea. Thus, nutritional status and cell-mediated immune status were important independent risk factors for persistent diarrhea.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - Jan 1 1993



  • Anthropometry
  • diarrhea
  • gastroenteritis
  • immunity
  • infants
  • nutrition disorders
  • nutritional status

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this