Cell-mediated immune deficiency and malnutrition are independent risk factors for persistent diarrhea in Bangladeshi children

Abdullah Baqui, R. Bradley Sack, Robert E Black, Hafizur R. Chowdhury, Mohammed Yunus, Abdul K. Siddique

Research output: Contribution to journalArticle

Abstract

A community-based longitudinal study was carried out at Matlab, Bangladesh, to investigate the magnitude of the problem of persistent diarrhea; 705 children aged <5 y were followed, yielding 7300 child-months of observation in 1 y. Morbidity data were collected every fourth day by home visit, anthropometric status was determined monthly, and cell-mediated immune status was assessed every 3 mo. The incidence of persistent diarrhea was 34 episodes per 100 child-years; rates were highest in infancy and declined through the remainder of childhood. In a logistic-regression model, weight-for-height status and immune status were significant predictors of persistent diarrhea. Compared with those at zero Z score, children with weight-for-height at -2 would have a 3.5 times increased risk of persistent diarrhea. Compared with immunocompetent children, immunodeficient children had about twice the risk of developing persistent diarrhea. Thus, nutritional status and cell-mediated immune status were important independent risk factors for persistent diarrhea.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume58
Issue number4
StatePublished - Oct 1993
Externally publishedYes

Fingerprint

immunosuppression
Malnutrition
malnutrition
Diarrhea
diarrhea
risk factors
cells
Logistic Models
Weights and Measures
House Calls
Bangladesh
infancy
longitudinal studies
Nutritional Status
childhood
Longitudinal Studies
morbidity
nutritional status
Observation
Morbidity

Keywords

  • Anthropometry
  • Diarrhea
  • Gastroenteritis
  • Immunity
  • Infants
  • Nutrition disorders
  • Nutritional status

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Cell-mediated immune deficiency and malnutrition are independent risk factors for persistent diarrhea in Bangladeshi children. / Baqui, Abdullah; Sack, R. Bradley; Black, Robert E; Chowdhury, Hafizur R.; Yunus, Mohammed; Siddique, Abdul K.

In: American Journal of Clinical Nutrition, Vol. 58, No. 4, 10.1993, p. 543-548.

Research output: Contribution to journalArticle

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