Cell-mediated cytotoxic responses of spleen cells from mice bearing primary, chemically induced tumors

C. I. Civin, N. Dorfman, A. Eggers, K. Fink, D. Penvose, C. K. Hsu, J. R. Wunderlich

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcomas were induced in C57BL/6 mice by using 3-methylcholanthrene. Spleen cells taken from these mice bearing primary, chemically induced tumors and from matched control mice were assessed for the capacity to generate cell-mediated cytotoxic cell activity after in vitro sensitization. Spleen cells from tumor-bearing mice generated strong cell-mediated cytotoxic responses against alloantigens and antigens on syngeneic cells.

Original languageEnglish (US)
Pages (from-to)2550-2557
Number of pages8
JournalJournal of Immunology
Volume123
Issue number6
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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