Cell labeling methods for noninvasive MR imaging of stem cells

Research output: Chapter in Book/Report/Conference proceedingChapter


MRI tracking of stem cells and progenitor cells is now widely being pursued in preclinical models of neurological diseases, including stroke. Typically, the cells of interest are labeled with superparamagnetic iron oxide (SPIO) particles that knock out the signal on the MR images. In this chapter, several methods are described that can be used to achieve intracellular SPIO labeling. In addition, some of the newer approaches are being discussed, in particular the use of perfluorocarbon emulsions for 19F hot spot MRI and MRI reporter genes, with the latter being the much sought-after holy grail for MRI cell tracking.

Original languageEnglish (US)
Title of host publicationCell-Based Therapies in Stroke
PublisherSpringer-Verlag Wien
Number of pages10
ISBN (Print)9783709111758, 9783709111741
Publication statusPublished - Jan 1 2013


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bulte, J. W. (2013). Cell labeling methods for noninvasive MR imaging of stem cells. In Cell-Based Therapies in Stroke (pp. 65-74). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1175-8_5