TY - CHAP
T1 - Cell death mechanisms of neurodegeneration
AU - Fan, Jing
AU - Dawson, Ted M.
AU - Dawson, Valina L.
N1 - Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017
Y1 - 2017
N2 - There are common mechanisms shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. This indicates that although the original cause may differ in individual diseases or even subtypes of certain disorders, these disrupted common cell functions and signaling, together with aging, may lead to final execution of cell death through similar pathways. The variable neurodegenerative disease symptoms are probably caused by the type, location, and connection of the cell populations that suffer from dysfunction and loss. Besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to PARP-1 overactivation, PAR accumulation, nuclear translocation of the mitochondria protein AIF, and large-scale DNA cleavage. Understanding the mechanisms and interactions of cell death signaling will not only help to develop neuroprotective strategies to halt neurodegeneration, but also provide biomarkers for monitoring disease progression and recovery.
AB - There are common mechanisms shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. This indicates that although the original cause may differ in individual diseases or even subtypes of certain disorders, these disrupted common cell functions and signaling, together with aging, may lead to final execution of cell death through similar pathways. The variable neurodegenerative disease symptoms are probably caused by the type, location, and connection of the cell populations that suffer from dysfunction and loss. Besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to PARP-1 overactivation, PAR accumulation, nuclear translocation of the mitochondria protein AIF, and large-scale DNA cleavage. Understanding the mechanisms and interactions of cell death signaling will not only help to develop neuroprotective strategies to halt neurodegeneration, but also provide biomarkers for monitoring disease progression and recovery.
KW - AIF
KW - Cell death
KW - Excitotoxicity
KW - Mitochondria
KW - Neurodegenerative diseases
KW - Nitric oxide
KW - Oxidative stress
KW - Parthanatos
UR - http://www.scopus.com/inward/record.url?scp=85021999939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021999939&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-57193-5_16
DO - 10.1007/978-3-319-57193-5_16
M3 - Chapter
C2 - 28674991
AN - SCOPUS:85021999939
T3 - Advances in Neurobiology
SP - 403
EP - 425
BT - Advances in Neurobiology
PB - Springer New York LLC
ER -