Cell death induced by prosthetic metal ions in human chondrocytes

P. Lonu, A. Srinivas, M. Overstreet, M. Hungerford, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The effect of metal ions on chondrocytes obtained from articular and nasal cartilage was evaluated. Cell death was evaluated by the lactate dyhydrogenase assay (LDH). Cells were incubated with metal ions such as cobalt (Co[II]), chromium (Cr[III]) and chromium (Cr[VI]). It was found that Co[II] and Cr[VI] ions induce chondrocyte death and that the nitric oxide pathway may be involved in the induction of lethal damage. The results show that exposure to critical concentrations of certain types of metal ions results in chondrocyte death, which could lead to the degradation of healthy cartilage.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)


Dive into the research topics of 'Cell death induced by prosthetic metal ions in human chondrocytes'. Together they form a unique fingerprint.

Cite this