Cell death induced by prosthetic metal ions in human chondrocytes

P. Lonu, A. Srinivas, M. Overstreet, M. Hungerford, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of metal ions on chondrocytes obtained from articular and nasal cartilage was evaluated. Cell death was evaluated by the lactate dyhydrogenase assay (LDH). Cells were incubated with metal ions such as cobalt (Co[II]), chromium (Cr[III]) and chromium (Cr[VI]). It was found that Co[II] and Cr[VI] ions induce chondrocyte death and that the nitric oxide pathway may be involved in the induction of lethal damage. The results show that exposure to critical concentrations of certain types of metal ions results in chondrocyte death, which could lead to the degradation of healthy cartilage.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1316
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Cell death
Prosthetics
Metal ions
Cartilage
Chromium
Nitric oxide
Cobalt
Assays
Degradation
Ions

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lonu, P., Srinivas, A., Overstreet, M., Hungerford, M., & Frondoza, C. G. (2004). Cell death induced by prosthetic metal ions in human chondrocytes. In Transactions - 7th World Biomaterials Congress (pp. 1316)

Cell death induced by prosthetic metal ions in human chondrocytes. / Lonu, P.; Srinivas, A.; Overstreet, M.; Hungerford, M.; Frondoza, C. G.

Transactions - 7th World Biomaterials Congress. 2004. p. 1316.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lonu, P, Srinivas, A, Overstreet, M, Hungerford, M & Frondoza, CG 2004, Cell death induced by prosthetic metal ions in human chondrocytes. in Transactions - 7th World Biomaterials Congress. pp. 1316, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Lonu P, Srinivas A, Overstreet M, Hungerford M, Frondoza CG. Cell death induced by prosthetic metal ions in human chondrocytes. In Transactions - 7th World Biomaterials Congress. 2004. p. 1316
Lonu, P. ; Srinivas, A. ; Overstreet, M. ; Hungerford, M. ; Frondoza, C. G. / Cell death induced by prosthetic metal ions in human chondrocytes. Transactions - 7th World Biomaterials Congress. 2004. pp. 1316
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