Cell death and cancer therapy

Research output: Contribution to journalReview article

Abstract

Successful cancer therapy requires the selective killing of cancer cells. Many molecular components of the pathways that lead to cell death have recently been identified and a number of these, including p53, Apaf-1, and members of the inhibitor of apoptosis protein and Bcl-2 gene families, have been found to be altered or disregulated in many cancers. These recent advances and the ongoing elucidation of how these pathways work is providing clues as to how therapeutically resistant cancers might be attacked.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume1
Issue number4
DOIs
StatePublished - Aug 1 2001

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Keywords

  • Anticancer
  • Apoptosis
  • Cancer Biology
  • Chemoresistance
  • Molecular Medicine
  • Pathway
  • Pharmacology
  • Therapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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