Abstract
DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 391-397 |
| Number of pages | 7 |
| Journal | Annals of Medicine |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2003 |
| Externally published | Yes |
Keywords
- Cancer syndromes
- Cell cycle
- DNA damage checkpoint
- DNA repair
ASJC Scopus subject areas
- General Medicine