Cell cycle control, DNA damage checkpoints and cancer

Marikki Laiho, Leena Latonen

Research output: Contribution to journalReview article

Abstract

DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalAnnals of Medicine
Volume35
Issue number6
DOIs
StatePublished - Oct 23 2003

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Keywords

  • Cancer syndromes
  • Cell cycle
  • DNA damage checkpoint
  • DNA repair

ASJC Scopus subject areas

  • Medicine(all)

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