Abstract
The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.
Original language | English (US) |
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Pages (from-to) | 568-574 |
Number of pages | 7 |
Journal | Current Opinion in Cell Biology |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology