TY - CHAP
T1 - Cell-based therapies for myocardial repair
T2 - Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart
AU - Da Silva, Jose S.
AU - Hare, Joshua M.
PY - 2013
Y1 - 2013
N2 - Accumulating data support the use of bone marrow (BM)-derived MSCs in animal models (e.g., swine) to restore cardiac function and tissue perfusion in chronic cardiac injury. Based on results obtained in swine, we are currently conducting phase I/II clinical trials to address the safety, cell type, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. MSCs for these trials are isolated from harvested BM and then processed and expanded for intracardiac injection. The BM-MSCs in use for the clinical trials are of clinical grade having been processed successfully in an FDA-approved cGMP facility.
AB - Accumulating data support the use of bone marrow (BM)-derived MSCs in animal models (e.g., swine) to restore cardiac function and tissue perfusion in chronic cardiac injury. Based on results obtained in swine, we are currently conducting phase I/II clinical trials to address the safety, cell type, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. MSCs for these trials are isolated from harvested BM and then processed and expanded for intracardiac injection. The BM-MSCs in use for the clinical trials are of clinical grade having been processed successfully in an FDA-approved cGMP facility.
UR - http://www.scopus.com/inward/record.url?scp=84885644604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885644604&partnerID=8YFLogxK
U2 - 10.1007/978-1-62703-505-7-8
DO - 10.1007/978-1-62703-505-7-8
M3 - Chapter
C2 - 24029934
SN - 9781627035040
VL - 1037
T3 - Methods in Molecular Biology
SP - 145
EP - 163
BT - Methods in Molecular Biology
ER -