Cell-based therapies for myocardial repair: Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart

Jose S. Da Silva, Joshua M. Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Accumulating data support the use of bone marrow (BM)-derived MSCs in animal models (e.g., swine) to restore cardiac function and tissue perfusion in chronic cardiac injury. Based on results obtained in swine, we are currently conducting phase I/II clinical trials to address the safety, cell type, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. MSCs for these trials are isolated from harvested BM and then processed and expanded for intracardiac injection. The BM-MSCs in use for the clinical trials are of clinical grade having been processed successfully in an FDA-approved cGMP facility.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages145-163
Number of pages19
Volume1037
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1037
ISSN (Print)10643745

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Cell-based therapies for myocardial repair: Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart'. Together they form a unique fingerprint.

  • Cite this

    Da Silva, J. S., & Hare, J. M. (2013). Cell-based therapies for myocardial repair: Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart. In Methods in Molecular Biology (Vol. 1037, pp. 145-163). (Methods in Molecular Biology; Vol. 1037). https://doi.org/10.1007/978-1-62703-505-7-8