Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells

Rosa Berga-Bolaños; Wandi S. Zhu; Farrah C. Steinke; Hai Hui Xue; Jyoti Misra Sen

doi:10.1016/j.molimm.2015.09.017

Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells

Rosa Berga-Bolaños, Wandi S. Zhu, Farrah C. Steinke, Hai Hui Xue, Jyoti Misra Sen

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Natural killer T (NKT) cells develop from common CD4⁺ CD8⁺ thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.

Original language	English (US)
Pages (from-to)	484-489
Number of pages	6
Journal	Molecular Immunology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/j.molimm.2015.09.017
State	Published - Dec 1 2015

Keywords

LEF1
NKT cells
TCF1

ASJC Scopus subject areas

Molecular Biology
Immunology

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10.1016/j.molimm.2015.09.017

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title = "Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells",

abstract = "Natural killer T (NKT) cells develop from common CD4+ CD8+ thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.",

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T1 - Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells

AU - Berga-Bolaños, Rosa

AU - Zhu, Wandi S.

AU - Steinke, Farrah C.

AU - Xue, Hai Hui

AU - Sen, Jyoti Misra

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AB - Natural killer T (NKT) cells develop from common CD4+ CD8+ thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.

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Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells

Abstract

Keywords

ASJC Scopus subject areas

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