Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells

Rosa Berga-Bolaños, Wandi S. Zhu, Farrah C. Steinke, Hai Hui Xue, Jyoti Misra Sen

Research output: Contribution to journalArticle

Abstract

Natural killer T (NKT) cells develop from common CD4+ CD8+ thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalMolecular Immunology
Volume68
Issue number2
DOIs
StatePublished - Dec 1 2015

Keywords

  • LEF1
  • NKT cells
  • TCF1

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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