TY - JOUR
T1 - Cell-associated infectious HIV-1 viral load as a predictor of clinical progression and survival among HIV-1 infected injection drug users and homosexual men
AU - Lyles, Cynthia M.
AU - Graham, Neil M.H.
AU - Astemborski, Jacquie
AU - Vlahov, David
AU - Margolick, Joseph B.
AU - Saah, Alfred J.
AU - Farzadegan, Homayoon
N1 - Funding Information:
This research was supported by NIH grants DA04334, AI-35042 and RR-00722. We would like to thank Beth A. Masters for performing the quantitative microculture assays and Melody A. Schaeffer, Terri Freedman and Veronica Stambolis for tracking participants and maintaining the outcomes database.
PY - 1999
Y1 - 1999
N2 - Cell-associated infectious HIV-1 viral load was measured using semi- quantitative microculture techniques to determine its predictive capability for progression to AIDS or survival among HIV-1 infected injecting drug users (IDU) and homosexual men (HM). The authors followed 296 IDU and 240 HM from February 1992 through September 1995 for: (i) death, (ii) AIDS, and (iii) AIDS or bacterial infection. At baseline, viral load was quantified using microculture techniques to determine infectious units per million peripheral blood mononuclear cells (IUPM). Data were analyzed using standard statistical methods for survival analysis. Of the 536 total participants, 106 died (20%), and 98 of the 481 AIDS-free participants developed AIDS (20%). The relative hazard of AIDS for a viral load of ≥ 100 IUPM, relative to a negative culture (0 IUPM), was 6.73 (95% CI: 2.23-20.3) after adjusting for risk group, initial CD4+ count, and other covariates. The adjusted relative hazard of death for a viral load of ≥100 IUPM vs. 0 IUPM was 2.57 (95% CI: 0.97-6.80). Viral load predicted time to death within the < 200 cells/μl CD4+ stratum. The predictive value of viral load on HIV-1 progression did not vary by risk group. These data show that cell associated infectious HIV- 1 viral load was significantly predictive of progression across risk groups for AIDS and death among those severely immune compromised.
AB - Cell-associated infectious HIV-1 viral load was measured using semi- quantitative microculture techniques to determine its predictive capability for progression to AIDS or survival among HIV-1 infected injecting drug users (IDU) and homosexual men (HM). The authors followed 296 IDU and 240 HM from February 1992 through September 1995 for: (i) death, (ii) AIDS, and (iii) AIDS or bacterial infection. At baseline, viral load was quantified using microculture techniques to determine infectious units per million peripheral blood mononuclear cells (IUPM). Data were analyzed using standard statistical methods for survival analysis. Of the 536 total participants, 106 died (20%), and 98 of the 481 AIDS-free participants developed AIDS (20%). The relative hazard of AIDS for a viral load of ≥ 100 IUPM, relative to a negative culture (0 IUPM), was 6.73 (95% CI: 2.23-20.3) after adjusting for risk group, initial CD4+ count, and other covariates. The adjusted relative hazard of death for a viral load of ≥100 IUPM vs. 0 IUPM was 2.57 (95% CI: 0.97-6.80). Viral load predicted time to death within the < 200 cells/μl CD4+ stratum. The predictive value of viral load on HIV-1 progression did not vary by risk group. These data show that cell associated infectious HIV- 1 viral load was significantly predictive of progression across risk groups for AIDS and death among those severely immune compromised.
KW - AIDS
KW - HIV-1
KW - Homosexuality
KW - Injection drug use
KW - Progression
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U2 - 10.1023/A:1007556327269
DO - 10.1023/A:1007556327269
M3 - Article
C2 - 10204638
AN - SCOPUS:0032978042
SN - 0393-2990
VL - 15
SP - 99
EP - 108
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 2
ER -