TY - JOUR
T1 - Cell adhesion molecules as tumour suppressors
AU - Hedrick, Lora
AU - Cho, Kathleen R.
AU - Vogelstein, Bert
PY - 1993/2
Y1 - 1993/2
N2 - Cell adhesion molecules, a diverse group of proteins expressed on the cell surface, have been implicated in numerous important cellular functions ranging from controlling morphogenesis to suppressing tumourigenesis. In this article, we discuss evidence supporting the idea that at least some proteins involved in cell adhesion may suppress tumourigenesis through influences on cell growth, differentiation and/or invasion. These studies suggest that some cell adhesion molecules may be encoded by tumour suppressor genes.
AB - Cell adhesion molecules, a diverse group of proteins expressed on the cell surface, have been implicated in numerous important cellular functions ranging from controlling morphogenesis to suppressing tumourigenesis. In this article, we discuss evidence supporting the idea that at least some proteins involved in cell adhesion may suppress tumourigenesis through influences on cell growth, differentiation and/or invasion. These studies suggest that some cell adhesion molecules may be encoded by tumour suppressor genes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027508937&partnerID=8YFLogxK
U2 - 10.1016/0962-8924(93)90148-T
DO - 10.1016/0962-8924(93)90148-T
M3 - Comment/debate
C2 - 14731716
AN - SCOPUS:0027508937
SN - 0962-8924
VL - 3
SP - 36
EP - 39
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -