Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages

Olaf Scheel, Martin Papavlassopoulos, Rikard Blunck, Andreas Gebert, Thomas Hartung, Ulrich Zähringer, Ulrich Seydel, Andra B. Schromm

Research output: Contribution to journalArticle

Abstract

Performing patch-clamp experiments on human macrophages, we show that the K+ channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.

Original languageEnglish (US)
Pages (from-to)4354-4356
Number of pages3
JournalInfection and immunity
Volume74
Issue number7
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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