TY - JOUR
T1 - Celiprolol, atenolol and propranolol
T2 - A comparison of pulmonary effects in asthmatic patients
AU - Doshan, Harold D.
AU - Rosenthal, Richard R.
AU - Brown, Robert
AU - Slutsky, Arthur
AU - Applin, Walter J.
AU - Caruso, Frank S.
PY - 1986
Y1 - 1986
N2 - Celiprolol, a new beta-adrenoccptor antagonist, blocks serotonin- and methacholine-mediated bronchoconstriction in animals (1,2), even in the presence of propranolol (3). In two, randomized, placebo-controlled, 5-way crossover trials, the pulmonary effects of celiprolol 200 and 400 mg, propranolol 40 mg and atenolol 100 mg were compared in 34 asthmatic patients. Pulmonary function was measured after single doses of each agent, and again following subsequent, graded doses of albuterol or isoproterenol aerosol. Changes in one-second forced expiratory volume (FEV1) and maximal midexpiratory flow rate (FEF25-75) prior to albuterol or isoproterenol were positive after placebo and both doses of celiprolol. Propranolol, and to a lesser extent, atenolol, caused significant reductions in both measures of pulmonary function.Overall changes in FEV1 following each drug plus isoproterenol or albuterol were positive, in the rank order, celiprolol ∼ placebo > atenolol > propranolol. Propranolol pretreatment caused a significant reduction in the effect of bronchodilator. Unlike atenolol and propranolol, celiprolol was highly bronchosparing and did not antagonize sympathomimetic bronchodilators.
AB - Celiprolol, a new beta-adrenoccptor antagonist, blocks serotonin- and methacholine-mediated bronchoconstriction in animals (1,2), even in the presence of propranolol (3). In two, randomized, placebo-controlled, 5-way crossover trials, the pulmonary effects of celiprolol 200 and 400 mg, propranolol 40 mg and atenolol 100 mg were compared in 34 asthmatic patients. Pulmonary function was measured after single doses of each agent, and again following subsequent, graded doses of albuterol or isoproterenol aerosol. Changes in one-second forced expiratory volume (FEV1) and maximal midexpiratory flow rate (FEF25-75) prior to albuterol or isoproterenol were positive after placebo and both doses of celiprolol. Propranolol, and to a lesser extent, atenolol, caused significant reductions in both measures of pulmonary function.Overall changes in FEV1 following each drug plus isoproterenol or albuterol were positive, in the rank order, celiprolol ∼ placebo > atenolol > propranolol. Propranolol pretreatment caused a significant reduction in the effect of bronchodilator. Unlike atenolol and propranolol, celiprolol was highly bronchosparing and did not antagonize sympathomimetic bronchodilators.
KW - Asthma
KW - Atenolol
KW - Beta-blocking
KW - Celiprolol
KW - Propranolol
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U2 - 10.1097/00005344-198608004-00023
DO - 10.1097/00005344-198608004-00023
M3 - Article
C2 - 2427836
AN - SCOPUS:0022918497
SN - 0160-2446
VL - 8
SP - S105-S108
JO - Journal of cardiovascular pharmacology
JF - Journal of cardiovascular pharmacology
ER -