Celiac disease and other nutrient related injuries to the gastrointestinal tract

Michael S Goggins, D. Kelleher

Research output: Contribution to journalArticle

Abstract

Celiac disease is the major nutrient-induced disease of the small intestine. The disease is traditionally characterized by villous atrophy responsive to gliadin. Recent data suggest that there is an extended spectrum of gluten sensitivity that includes first-degree relatives and patients with latent celiac disease. Genetic studies have identified HLA DQ A1 *0501 B1 *0201 as the predominant HLA gene most tightly linked to this condition. Gliadin-specific T cells clones restricted by DQ have now been identified in the small intestine lamina propria. Such T cells may be important in mediating many of the features of the disease. This review discusses the interrelationship of genetics, cereal chemistry, environmental factors, and immunology involved in the pathogenesis of celiac disease and explores its relationship with other nutrient-induced enteropathies.

Original languageEnglish (US)
JournalAmerican Journal of Gastroenterology
Volume89
Issue number8 SUPPL.
StatePublished - 1994
Externally publishedYes

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Celiac Disease
Gastrointestinal Tract
Gliadin
Food
Small Intestine
Wounds and Injuries
HLA-A1 Antigen
HLA-DQ Antigens
T-Lymphocytes
Glutens
Allergy and Immunology
Atrophy
Mucous Membrane
Clone Cells
Genes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Celiac disease and other nutrient related injuries to the gastrointestinal tract. / Goggins, Michael S; Kelleher, D.

In: American Journal of Gastroenterology, Vol. 89, No. 8 SUPPL., 1994.

Research output: Contribution to journalArticle

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