TY - JOUR
T1 - Ceftriaxone compared with cefotaxime for serious bacterial infections
AU - Smith, Craig R.
AU - Petty, Brent G.
AU - Hendrix, Craig W.
AU - Kernan, Walter N.
AU - Garver, Patty L.
AU - Fox, Kevin
AU - Beamer, Andrew
AU - Carbone, Kathy
AU - Threlkeld, Michael
AU - Lietman, Paul S.
PY - 1989/9
Y1 - 1989/9
N2 - Ceftriaxone was compared with cefotaxime for the treatment of serious bacterial infections in a prospective, randomized, double-blind clinical trial. The dose of ceftriaxone was 2 g once a day, and the dose of cefotaxime was 2 g every 4 h. Metronidazole was added if anaerobic infection was suspected. Explicit criteria were used to define infections, clinical response, and adverse effects. Ceftriaxone wasgiven to 88patients and cefotaxime to 83. The two treatment groups did not differ in types of infection, infecting organisms, and severity of underlying disease. The response rate was 81070 (71/88) for ceftriaxone and 80% (66/83) for cefotaxime. The power of the study to detect a 15% difference in response rate at P<.1was 90070. The frequency of diarrhea, thrombophlebitis, prothrombin time, prolongation, colonization, and superinfection did not differ between treatment groups. Ceftriaxone 2 g once a day was as safe and effective as cefotaxime 2 g every 4 h for suspected serious bacterial infections.
AB - Ceftriaxone was compared with cefotaxime for the treatment of serious bacterial infections in a prospective, randomized, double-blind clinical trial. The dose of ceftriaxone was 2 g once a day, and the dose of cefotaxime was 2 g every 4 h. Metronidazole was added if anaerobic infection was suspected. Explicit criteria were used to define infections, clinical response, and adverse effects. Ceftriaxone wasgiven to 88patients and cefotaxime to 83. The two treatment groups did not differ in types of infection, infecting organisms, and severity of underlying disease. The response rate was 81070 (71/88) for ceftriaxone and 80% (66/83) for cefotaxime. The power of the study to detect a 15% difference in response rate at P<.1was 90070. The frequency of diarrhea, thrombophlebitis, prothrombin time, prolongation, colonization, and superinfection did not differ between treatment groups. Ceftriaxone 2 g once a day was as safe and effective as cefotaxime 2 g every 4 h for suspected serious bacterial infections.
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U2 - 10.1093/infdis/160.3.442
DO - 10.1093/infdis/160.3.442
M3 - Article
C2 - 2668428
AN - SCOPUS:0024348525
SN - 0022-1899
VL - 160
SP - 442
EP - 447
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -