cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei

D. Hereld; G. W. Hart; P. T. Englund

doi:10.1073/pnas.85.23.8914

cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei

D. Hereld, G. W. Hart, P. T. Englund

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei.

Original language	English (US)
Pages (from-to)	8914-8918
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	85
Issue number	23
DOIs	https://doi.org/10.1073/pnas.85.23.8914
State	Published - 1988
Externally published	Yes

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abstract = "VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei.",

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AU - Hereld, D.

AU - Hart, G. W.

AU - Englund, P. T.

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Y1 - 1988

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AB - VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei.

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cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei

Abstract

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