cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei

D. Hereld, G. W. Hart, P. T. Englund

Research output: Contribution to journalArticle

Abstract

VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei.

Original languageEnglish (US)
Pages (from-to)8914-8918
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number23
DOIs
StatePublished - 1988

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