cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases

H. Shao, L. Lou, Akhilesh Pandey, M. F. Verderame, D. A. Siever, V. M. Dixit

Research output: Contribution to journalArticle

Abstract

We have isolated a murine cDNA encoding a ligand for the Cek7 receptor protein-tyrosine kinase (RPTK), a member of the Eph/Eck RPTK subfamily. Sequence analysis predicts an open reading frame of 209 amino acids with a predicted molecular mass of 24 kDa. The Cek7 ligand shows a 48% sequence identity at the protein level to B61, a ligand for the related Eck RPTK, 30% to the Cek5 ligand, 59% to the recently cloned Ehk1-L, and identity to ELF- 1, a recently described ligand for the Mek4 and Sek RPTKs. The expressed Cek7 ligand is functionally active as it induces autophosphorylation of the Cek7 RPTK.

Original languageEnglish (US)
Pages (from-to)3467-3470
Number of pages4
JournalJournal of Biological Chemistry
Volume270
Issue number8
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases'. Together they form a unique fingerprint.

  • Cite this