Abstract
CDK12 inactivation in prostate cancer is associated with tandem genomic duplications that may generate fusion-associated neoantigens and elicit immune responses amenable to checkpoint blockade. In the first study to comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4þFOXP3 T cells were increased compared with CDK12-proficient controls.
Original language | English (US) |
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Pages (from-to) | 380-382 |
Number of pages | 3 |
Journal | Clinical Cancer Research |
Volume | 27 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2021 |
ASJC Scopus subject areas
- Oncology
- Cancer Research