CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect

Ian A. Cockburn, Sze Wah Tse, Fidel Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

Immunization with attenuated Plasmodium sporozoites or viral vectored vaccines can induce protective CD8+ T cells that can find and eliminate liver-stage malaria parasites. A key question is whether CD8+ T cells must recognize and eliminate each parasite in the liver or whether bystander killing can occur. To test this, we transferred antigen-specific effector CD8+ T cells to mice that were then coinfected with two Plasmodium berghei strains, only one of which could be recognized directly by the transferred T cells. We found that the noncognate parasites developed normally in these mice, demonstrating that bystander killing of parasites does not occur during the CD8+ T cell response to malaria parasites. Rather, elimination of infected parasites is likely mediated by direct recognition of infected hepatocytes by antigen-specific CD8+ T cells.

Original languageEnglish (US)
Pages (from-to)1460-1464
Number of pages5
JournalInfection and immunity
Volume82
Issue number4
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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