CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants

Andrew D. Redd; Alessandra Nardin; Hassen Kared; Evan M. Bloch; Andrew Pekosz; Oliver Laeyendecker; Brian Abel; Michael Fehlings; Thomas C. Quinn; Aaron A.R. Tobian

doi:10.1093/ofid/ofab143

CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants

Andrew D. Redd, Alessandra Nardin, Hassen Kared, Evan M. Bloch, Andrew Pekosz, Oliver Laeyendecker, Brian Abel, Michael Fehlings, Thomas C. Quinn, Aaron A.R. Tobian

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

Original language	English (US)
Article number	ofab143
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofab143
State	Published - Jul 2021

Keywords

CD8+ T cell
COVID-19
SARS-CoV-2
convalescent patients

ASJC Scopus subject areas

Oncology
Clinical Neurology

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10.1093/ofid/ofab143

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Redd, A. D., Nardin, A., Kared, H., Bloch, E. M., Pekosz, A., Laeyendecker, O., Abel, B., Fehlings, M., Quinn, T. C., & Tobian, A. A. R. (2021). CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants. Open Forum Infectious Diseases, 8(7), Article ofab143. https://doi.org/10.1093/ofid/ofab143

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abstract = "This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.",

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year = "2021",

month = jul,

doi = "10.1093/ofid/ofab143",

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AU - Redd, Andrew D.

AU - Nardin, Alessandra

AU - Kared, Hassen

AU - Bloch, Evan M.

AU - Pekosz, Andrew

AU - Laeyendecker, Oliver

AU - Abel, Brian

AU - Fehlings, Michael

AU - Quinn, Thomas C.

AU - Tobian, Aaron A.R.

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KW - CD8+ T cell

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KW - SARS-CoV-2

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CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants

Abstract

Keywords

ASJC Scopus subject areas

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