CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus

Research output: Research - peer-reviewArticle

Abstract

Background. Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role. Methods. To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection. Results. A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4+ T-cell counts 3 after HIV infection, and subjects with CD4+ T-cell counts 3 also showed a reduction in nAb breadth. Subjects who maintained CD4+ T-cell counts ≥350/mm3 displayed little to no decline in antibody levels. Conclusions. Depletion of CD4+ T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.

LanguageEnglish (US)
Pages914-923
Number of pages10
JournalJournal of Infectious Diseases
Volume212
Issue number6
DOIs
StatePublished - Sep 15 2015
Externally publishedYes

Fingerprint

Neutralizing Antibodies
Coinfection
Hepacivirus
Antibody Formation
HIV
T-Lymphocytes
Virus Diseases
Antibodies
Cell Count
Hepatitis C Antibodies
Virus Attachment
Viremia
Humoral Immunity
Fibrosis
Infection
Serum

Keywords

  • coinfection
  • HCV
  • HIV
  • neutralizing antibody

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

@article{8faf40a0bbbc48ceb28e35793bc1ba30,
title = "CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus",
abstract = "Background. Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role. Methods. To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection. Results. A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4+ T-cell counts 3 after HIV infection, and subjects with CD4+ T-cell counts 3 also showed a reduction in nAb breadth. Subjects who maintained CD4+ T-cell counts ≥350/mm3 displayed little to no decline in antibody levels. Conclusions. Depletion of CD4+ T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.",
keywords = "coinfection, HCV, HIV, neutralizing antibody",
author = "Bailey, {Justin R.} and Dowd, {Kimberly A.} and Snider, {Anna E.} and Osburn, {William O.} and Mehta, {Shruti H.} and Kirk, {Gregory D.} and Thomas, {David L.} and Ray, {Stuart C.}",
year = "2015",
month = "9",
doi = "10.1093/infdis/jiv139",
volume = "212",
pages = "914--923",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus

AU - Bailey,Justin R.

AU - Dowd,Kimberly A.

AU - Snider,Anna E.

AU - Osburn,William O.

AU - Mehta,Shruti H.

AU - Kirk,Gregory D.

AU - Thomas,David L.

AU - Ray,Stuart C.

PY - 2015/9/15

Y1 - 2015/9/15

N2 - Background. Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role. Methods. To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection. Results. A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4+ T-cell counts 3 after HIV infection, and subjects with CD4+ T-cell counts 3 also showed a reduction in nAb breadth. Subjects who maintained CD4+ T-cell counts ≥350/mm3 displayed little to no decline in antibody levels. Conclusions. Depletion of CD4+ T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.

AB - Background. Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role. Methods. To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection. Results. A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4+ T-cell counts 3 after HIV infection, and subjects with CD4+ T-cell counts 3 also showed a reduction in nAb breadth. Subjects who maintained CD4+ T-cell counts ≥350/mm3 displayed little to no decline in antibody levels. Conclusions. Depletion of CD4+ T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.

KW - coinfection

KW - HCV

KW - HIV

KW - neutralizing antibody

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