TY - JOUR
T1 - CD4+ cytolytic T cell clone confers protection against murine malaria
AU - Tsuji, Moriya
AU - Romero, Pedro
AU - Nussenzweig, Ruth S.
AU - Zavala, Fidel
PY - 1990/11/1
Y1 - 1990/11/1
N2 - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
AB - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
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U2 - 10.1084/jem.172.5.1353
DO - 10.1084/jem.172.5.1353
M3 - Article
C2 - 2146361
AN - SCOPUS:0025038617
VL - 172
SP - 1353
EP - 1357
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 5
ER -