CD4+ cytolytic T cell clone confers protection against murine malaria

Moriya Tsuji, Pedro Romero, Ruth S. Nussenzweig, Fidel Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

Original languageEnglish (US)
Pages (from-to)1353-1357
Number of pages5
JournalJournal of Experimental Medicine
Volume172
Issue number5
DOIs
StatePublished - Nov 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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