CD4+ cytolytic T cell clone confers protection against murine malaria

Moriya Tsuji; Pedro Romero; Ruth S. Nussenzweig; Fidel Zavala

doi:10.1084/jem.172.5.1353

CD4⁺ cytolytic T cell clone confers protection against murine malaria

Moriya Tsuji, Pedro Romero, Ruth S. Nussenzweig, Fidel Zavala

Research output: Contribution to journal › Article › peer-review

Abstract

A CD4⁺ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-E^d molecule. Passive transfer of this CD4⁺ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

Original language	English (US)
Pages (from-to)	1353-1357
Number of pages	5
Journal	Journal of Experimental Medicine
Volume	172
Issue number	5
DOIs	https://doi.org/10.1084/jem.172.5.1353
State	Published - Nov 1 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "CD4+ cytolytic T cell clone confers protection against murine malaria",

abstract = "A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.",

author = "Moriya Tsuji and Pedro Romero and Nussenzweig, {Ruth S.} and Fidel Zavala",

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AU - Tsuji, Moriya

AU - Romero, Pedro

AU - Nussenzweig, Ruth S.

AU - Zavala, Fidel

PY - 1990/11/1

Y1 - 1990/11/1

N2 - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

AB - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

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