CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

Leslie R. Cockerham; Janet D. Siliciano; Elizabeth Sinclair; Una O'Doherty; Sarah Palmer; Steven A. Yukl; Matt C. Strain; Nicolas Chomont; Frederick M. Hecht; Robert F. Siliciano; Douglas D. Richman; Steven G. Deeks

doi:10.1371/journal.pone.0110731

CD4⁺ and CD8⁺ T cell activation are associated with HIV DNA in resting CD4⁺ T cells

Leslie R. Cockerham, Janet D. Siliciano, Elizabeth Sinclair, Una O'Doherty, Sarah Palmer, Steven A. Yukl, Matt C. Strain, Nicolas Chomont, Frederick M. Hecht, Robert F. Siliciano, Douglas D. Richman, Steven G. Deeks

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Abstract

The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4⁺ and CD8⁺ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

Original language	English (US)
Article number	e110731
Journal	PloS one
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0110731
State	Published - Oct 23 2014

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title = "CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells",

abstract = "The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.",

author = "Cockerham, {Leslie R.} and Siliciano, {Janet D.} and Elizabeth Sinclair and Una O'Doherty and Sarah Palmer and Yukl, {Steven A.} and Strain, {Matt C.} and Nicolas Chomont and Hecht, {Frederick M.} and Siliciano, {Robert F.} and Richman, {Douglas D.} and Deeks, {Steven G.}",

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AU - Cockerham, Leslie R.

AU - Siliciano, Janet D.

AU - Sinclair, Elizabeth

AU - O'Doherty, Una

AU - Palmer, Sarah

AU - Yukl, Steven A.

AU - Strain, Matt C.

AU - Chomont, Nicolas

AU - Hecht, Frederick M.

AU - Siliciano, Robert F.

AU - Richman, Douglas D.

AU - Deeks, Steven G.

PY - 2014/10/23

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N2 - The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

AB - The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

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CD4⁺ and CD8⁺ T cell activation are associated with HIV DNA in resting CD4⁺ T cells

Abstract

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