CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford

Research output: Contribution to journalArticlepeer-review

Abstract

Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.

Original languageEnglish (US)
Pages (from-to)1282-1291.e5
JournalCell Reports
Volume30
Issue number5
DOIs
StatePublished - Feb 4 2020
Externally publishedYes

Keywords

  • CD45
  • T cell memory
  • TCR affinity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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