CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

A. G M Stam, S. J A M Santegoets, T. M. Westers, C. C. Sombroek, J. J W M Janssen, B. W. Tillman, A. A. Van De Loosdrecht, H. M. Pinedo, D. T. Curiel, G. J. Ossenkoppele, R. J. Scheper, T. D. De Gruijl

Research output: Contribution to journalArticle

Abstract

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

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Keywords

  • Adenovirus
  • CD40 ligation
  • CML
  • Dendritic cell
  • GM-CSF
  • Immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Stam, A. G. M., Santegoets, S. J. A. M., Westers, T. M., Sombroek, C. C., Janssen, J. J. W. M., Tillman, B. W., ... De Gruijl, T. D. (2003). CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation. British Journal of Cancer, 89(7), 1162-1165. https://doi.org/10.1038/sj.bjc.6601225