CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

A. G M Stam, S. J A M Santegoets, T. M. Westers, C. C. Sombroek, J. J W M Janssen, B. W. Tillman, A. A. Van De Loosdrecht, H. M. Pinedo, D. T. Curiel, G. J. Ossenkoppele, R. J. Scheper, T. D. De Gruijl

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

Original languageEnglish (US)
Pages (from-to)1162-1165
Number of pages4
JournalBritish Journal of Cancer
Volume89
Issue number7
DOIs
StatePublished - Oct 6 2003
Externally publishedYes

Keywords

  • Adenovirus
  • CD40 ligation
  • CML
  • Dendritic cell
  • GM-CSF
  • Immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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