CD4+ cytolytic T cell clone confers protection against murine malaria

Moriya Tsuji, Pedro Romero, Ruth S. Nussenzweig, Fidel P Zavala

Research output: Contribution to journalArticle

Abstract

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

Original languageEnglish (US)
Pages (from-to)1353-1357
Number of pages5
JournalJournal of Experimental Medicine
Volume172
Issue number5
StatePublished - Nov 1 1990
Externally publishedYes

Fingerprint

Sporozoites
Malaria
Clone Cells
T-Lymphocytes
Antigens
Plasmodium berghei
Interleukin-2
Spleen
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

CD4+ cytolytic T cell clone confers protection against murine malaria. / Tsuji, Moriya; Romero, Pedro; Nussenzweig, Ruth S.; Zavala, Fidel P.

In: Journal of Experimental Medicine, Vol. 172, No. 5, 01.11.1990, p. 1353-1357.

Research output: Contribution to journalArticle

Tsuji, M, Romero, P, Nussenzweig, RS & Zavala, FP 1990, 'CD4+ cytolytic T cell clone confers protection against murine malaria', Journal of Experimental Medicine, vol. 172, no. 5, pp. 1353-1357.
Tsuji, Moriya ; Romero, Pedro ; Nussenzweig, Ruth S. ; Zavala, Fidel P. / CD4+ cytolytic T cell clone confers protection against murine malaria. In: Journal of Experimental Medicine. 1990 ; Vol. 172, No. 5. pp. 1353-1357.
@article{8474aea37b984318b4845c85625d9ac5,
title = "CD4+ cytolytic T cell clone confers protection against murine malaria",
abstract = "A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.",
author = "Moriya Tsuji and Pedro Romero and Nussenzweig, {Ruth S.} and Zavala, {Fidel P}",
year = "1990",
month = "11",
day = "1",
language = "English (US)",
volume = "172",
pages = "1353--1357",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "5",

}

TY - JOUR

T1 - CD4+ cytolytic T cell clone confers protection against murine malaria

AU - Tsuji, Moriya

AU - Romero, Pedro

AU - Nussenzweig, Ruth S.

AU - Zavala, Fidel P

PY - 1990/11/1

Y1 - 1990/11/1

N2 - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

AB - A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

UR - http://www.scopus.com/inward/record.url?scp=0025038617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025038617&partnerID=8YFLogxK

M3 - Article

C2 - 2146361

AN - SCOPUS:0025038617

VL - 172

SP - 1353

EP - 1357

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 5

ER -