CD4 count outperforms World Health Organization clinical algorithm for point-of-care HIV diagnosis among hospitalised HIV-exposed Malawian infants

Madalitso Maliwichi, Nora E. Rosenberg, Rebekah Macfie, Dan Olson, Irving Hoffman, Charles M. van der Horst, Peter N. Kazembe, Mina C. Hosseinipour, Eric McCollum

Research output: Contribution to journalArticle

Abstract

Objective: To determine, for the WHO algorithm for point-of-care diagnosis of HIV infection, the agreement levels between paediatricians and non-physician clinicians, and to compare sensitivity and specificity profiles of the WHO algorithm and different CD4 thresholds against HIV PCR testing in hospitalised Malawian infants. Methods: In 2011, hospitalised HIV-exposed infants 3 by paediatricians and clinical officers. Results: We enrolled 166 infants (50% female, 34% 3 or 3 could identify more HIV-infected infants with fewer false positives than the algorithm. However, a point-of-care option with better performance characteristics is needed for accurate, timely HIV diagnosis.

Original languageEnglish (US)
Pages (from-to)978-987
Number of pages10
JournalTropical Medicine and International Health
Volume19
Issue number8
DOIs
StatePublished - 2014

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Point-of-Care Systems
CD4 Lymphocyte Count
HIV
HIV Infections
Sensitivity and Specificity
Polymerase Chain Reaction

Keywords

  • Africa
  • Clinical algorithm
  • Early infant diagnosis
  • HIV
  • Paediatric
  • Point-of-care

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology

Cite this

CD4 count outperforms World Health Organization clinical algorithm for point-of-care HIV diagnosis among hospitalised HIV-exposed Malawian infants. / Maliwichi, Madalitso; Rosenberg, Nora E.; Macfie, Rebekah; Olson, Dan; Hoffman, Irving; van der Horst, Charles M.; Kazembe, Peter N.; Hosseinipour, Mina C.; McCollum, Eric.

In: Tropical Medicine and International Health, Vol. 19, No. 8, 2014, p. 978-987.

Research output: Contribution to journalArticle

Maliwichi, Madalitso ; Rosenberg, Nora E. ; Macfie, Rebekah ; Olson, Dan ; Hoffman, Irving ; van der Horst, Charles M. ; Kazembe, Peter N. ; Hosseinipour, Mina C. ; McCollum, Eric. / CD4 count outperforms World Health Organization clinical algorithm for point-of-care HIV diagnosis among hospitalised HIV-exposed Malawian infants. In: Tropical Medicine and International Health. 2014 ; Vol. 19, No. 8. pp. 978-987.
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