CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal during Cardiac Remodeling

Kristine Y. Deleon-Pennell, Yuan Tian, Bai Zhang, Courtney A. Cates, Rugmani Padmanabhan Iyer, Presley Cannon, Punit Shah, Paul Aiyetan, Ganesh V. Halade, Yonggang Ma, Elizabeth Flynn, Zhen Zhang, Yu Fang Jin, Hui Zhang, Merry L. Lindsey

Research output: Contribution to journalArticle

Abstract

Background-After myocardial infarction, the left ventricle undergoes a wound healing response that includes the robust infiltration of neutrophils and macrophages to facilitate removal of dead myocytes as well as turnover of the extracellular matrix. Matrix metalloproteinase (MMP)-9 is a key enzyme that regulates post-myocardial infarction left ventricular remodeling. Methods and Results-Infarct regions from wild-type and MMP-9 null mice (n=8 per group) analyzed by glycoproteomics showed that of 541 N-glycosylated proteins quantified, 45 proteins were at least 2-fold upregulated or downregulated with MMP-9 deletion (all P

Original languageEnglish (US)
Pages (from-to)14-25
Number of pages12
JournalCirculation: Cardiovascular Genetics
Volume9
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Matrix Metalloproteinase 9
Neutrophils
Apoptosis
Myocardial Infarction
Ventricular Remodeling
Neutrophil Infiltration
Wound Healing
Muscle Cells
Heart Ventricles
Extracellular Matrix
Proteins
Down-Regulation
Macrophages
Enzymes

Keywords

  • extracellular matrix
  • immunoblotting
  • infarction
  • inflammation
  • myocardial
  • proteomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics

Cite this

CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal during Cardiac Remodeling. / Deleon-Pennell, Kristine Y.; Tian, Yuan; Zhang, Bai; Cates, Courtney A.; Iyer, Rugmani Padmanabhan; Cannon, Presley; Shah, Punit; Aiyetan, Paul; Halade, Ganesh V.; Ma, Yonggang; Flynn, Elizabeth; Zhang, Zhen; Jin, Yu Fang; Zhang, Hui; Lindsey, Merry L.

In: Circulation: Cardiovascular Genetics, Vol. 9, No. 1, 01.02.2016, p. 14-25.

Research output: Contribution to journalArticle

Deleon-Pennell, KY, Tian, Y, Zhang, B, Cates, CA, Iyer, RP, Cannon, P, Shah, P, Aiyetan, P, Halade, GV, Ma, Y, Flynn, E, Zhang, Z, Jin, YF, Zhang, H & Lindsey, ML 2016, 'CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal during Cardiac Remodeling', Circulation: Cardiovascular Genetics, vol. 9, no. 1, pp. 14-25. https://doi.org/10.1161/CIRCGENETICS.115.001249
Deleon-Pennell, Kristine Y. ; Tian, Yuan ; Zhang, Bai ; Cates, Courtney A. ; Iyer, Rugmani Padmanabhan ; Cannon, Presley ; Shah, Punit ; Aiyetan, Paul ; Halade, Ganesh V. ; Ma, Yonggang ; Flynn, Elizabeth ; Zhang, Zhen ; Jin, Yu Fang ; Zhang, Hui ; Lindsey, Merry L. / CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal during Cardiac Remodeling. In: Circulation: Cardiovascular Genetics. 2016 ; Vol. 9, No. 1. pp. 14-25.
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