CD34+ selection and the severity of oropharyngeal mucositis in total body irradiation-based allogeneic stem cell transplantation

Ankit Anand, Prathima Anandi, Natasha A. Jain, Kit Lu, Neil Dunavin, Christopher S. Hourigan, Robert Q. Le, Puja D. Chokshi, Sawa Ito, David F. Stroncek, Marianna Sabatino, A. John Barrett, Minoo Battiwalla

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of the present study was to evaluate the impact of ex vivo T cell depleted (TCD) by CD34+ selection on the incidence and severity of oropharyngeal mucositis (OM) after myeloablative allogeneic stem cell transplant (allo-SCT) with total body irradiation (TBI) conditioning. This approach has the advantage of avoiding methotrexate for graft versus host disease (GVHD) prophylaxis. Patients and Methods: We analyzed the incidence and severity of OM in a cohort of 105 consecutive patients who underwent CD34+ selected (peripheral blood stem cells (PBSCs) from human leukocyte antigen (HLA)-identical siblings) allo-SCT with total body irradiation (TBI) conditioning. OM was graded by the World Health organization (WHO) and the Bearman regimen-related toxicity (RRT) scales. Results: The incidence of WHO grade 3–4 OM was 34.3 %. There were no cases of grade 3–4 OM by the RRT scale. Significant correlation was found between the severity of OM and the use of intravenous (IV) narcotic medications (r2 = 0.15, p = 0.004), total parenteral nutrition (TPN; r2 = 0.68, p < 0.001), and hospital length of stay (LOS) (r2 = 0.12, p = 0.01). Discussion: TBI-induced OM can inflict significant morbidity in the early transplant period, and the incidence of WHO grade 3–4 OM can exceed 50 % when methotrexate is used for GVHD prophylaxis. In the CD34+ selected setting, methotrexate is avoided and the incidence of WHO grade 3–4 OM, use of TPN, and need for narcotic analgesia appear to be lower than historic evidence from standard T-replete allogeneic transplantation. Conclusion: We conclude that toxicity from OM is tolerable in CD34+ selected allo-SCT and should be prospectively measured in randomized trials comparing CD34+ selection versus T-replete transplantation.

Original languageEnglish (US)
Pages (from-to)815-822
Number of pages8
JournalSupportive Care in Cancer
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

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Keywords

  • Allogeneic
  • CD34 selection
  • Methotrexate
  • Oral mucositis
  • Oropharyngeal mucositis
  • Quality of life
  • Stem cell transplant
  • T cell depleted transplantation
  • Total body irradiation

ASJC Scopus subject areas

  • Oncology

Cite this

Anand, A., Anandi, P., Jain, N. A., Lu, K., Dunavin, N., Hourigan, C. S., Le, R. Q., Chokshi, P. D., Ito, S., Stroncek, D. F., Sabatino, M., Barrett, A. J., & Battiwalla, M. (2016). CD34+ selection and the severity of oropharyngeal mucositis in total body irradiation-based allogeneic stem cell transplantation. Supportive Care in Cancer, 24(2), 815-822. https://doi.org/10.1007/s00520-015-2848-9