CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

Siân Lax, Ewan A. Ross, Andrea White, Jennifer L. Marshall, William E. Jenkinson, Clare M. Isacke, David L. Huso, Adam F. Cunningham, Graham Anderson, Christopher D. Buckley

Research output: Contribution to journalArticle

Abstract

The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248 -/- mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalFEBS Open Bio
Volume2
DOIs
StatePublished - 2012

Fingerprint

Thymus
Mesenchymal Stromal Cells
Thymus Gland
Regeneration
Infection
Pericytes
Salmonella
Salmonella Infections
Thymocytes
Population

Keywords

  • CD248
  • Endosialin
  • MSC
  • Thymus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lax, S., Ross, E. A., White, A., Marshall, J. L., Jenkinson, W. E., Isacke, C. M., ... Buckley, C. D. (2012). CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. FEBS Open Bio, 2, 187-190. https://doi.org/10.1016/j.fob.2012.07.003

CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. / Lax, Siân; Ross, Ewan A.; White, Andrea; Marshall, Jennifer L.; Jenkinson, William E.; Isacke, Clare M.; Huso, David L.; Cunningham, Adam F.; Anderson, Graham; Buckley, Christopher D.

In: FEBS Open Bio, Vol. 2, 2012, p. 187-190.

Research output: Contribution to journalArticle

Lax, S, Ross, EA, White, A, Marshall, JL, Jenkinson, WE, Isacke, CM, Huso, DL, Cunningham, AF, Anderson, G & Buckley, CD 2012, 'CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration', FEBS Open Bio, vol. 2, pp. 187-190. https://doi.org/10.1016/j.fob.2012.07.003
Lax, Siân ; Ross, Ewan A. ; White, Andrea ; Marshall, Jennifer L. ; Jenkinson, William E. ; Isacke, Clare M. ; Huso, David L. ; Cunningham, Adam F. ; Anderson, Graham ; Buckley, Christopher D. / CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. In: FEBS Open Bio. 2012 ; Vol. 2. pp. 187-190.
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