CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

Siân Lax, Ewan A. Ross, Andrea White, Jennifer L. Marshall, William E. Jenkinson, Clare M. Isacke, David L. Huso, Adam F. Cunningham, Graham Anderson, Christopher D. Buckley

Research output: Contribution to journalArticlepeer-review

Abstract

The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248 -/- mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalFEBS Open Bio
Volume2
DOIs
StatePublished - 2012

Keywords

  • CD248
  • Endosialin
  • MSC
  • Thymus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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