Abstract
The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248 -/- mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.
Original language | English (US) |
---|---|
Pages (from-to) | 187-190 |
Number of pages | 4 |
Journal | FEBS Open Bio |
Volume | 2 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Keywords
- CD248
- Endosialin
- MSC
- Thymus
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology