Abstract
Experimental autoimmune thyroiditis (EAT), a model for Hashimoto's thyroiditis, is a T cell-mediated disease inducible with mouse thyroglobulin (mTg). Pretreatment with mTg, however, can induce CD4+ T cell-mediated tolerance to EAT. We demonstrate that CD4+CD25 + regulatory cells are critical for the tolerance induction, as in vivo depletion of CD25+ cells abrogated established tolerance, and CD4+CD25+ cells from tolerized mice suppressed mTg-responsive cells in vitro. Importantly, administration of an agonistic CD137 monoclonal antibody (mAb) inhibited tolerance development, and the mediation of established tolerance. CD137 mAb also inhibited the suppression of mTg-responsive cells by CD4+CD25+ cells in vitro. Signaling through CD137 likely resulted in enhancement of the responding inflammatory T cells, as anti-CD137 did not enable CD4+CD25 + T cells to proliferate in response to mTg in vitro.
Original language | English (US) |
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Pages (from-to) | 20-29 |
Number of pages | 10 |
Journal | Cellular Immunology |
Volume | 226 |
Issue number | 1 |
DOIs | |
State | Published - Nov 2003 |
Externally published | Yes |
Keywords
- 4-1BB
- Autoimmunity
- CD137
- CD25
- Experimental autoimmune thyroiditis
- Regulatory T cells
ASJC Scopus subject areas
- Cell Biology
- Immunology