CCK(A) and 5-HT3 receptors interact in anorectic responses to amino acid deficiency

S. M. Aja, J. A. Barrett, D. W. Gietzen

Research output: Contribution to journalArticlepeer-review


Serotonin3 (5-HT3) receptors in the periphery mediate anorectic responses to the amino acid deficiency, which occurs after eating amino acid-imbalanced diets (IMB). However, other neurochemical systems, notably cholecystokinin (CCK), are known to affect food intake. We pretreated rats systemically with tropisetron, a 5-HT3 receptor antagonist, alone and combined with antagonists of CCK(A) and CCK(B) receptors, and measured intake of an IMB. Devazepide, a CCK(A) receptor antagonist, appeared to interact with tropisetron in the anorectic responses to IMB, blunting the usual remediation of IMB anorexia by tropisetron. The CCK(B) receptor antagonist, L-365, 260, increased intake of both IMB and an amino acid-balanced basal diet (BAS) and did not interact with tropisetron. Our data suggest that activation of CCK(A) receptors is interactive with 5-HT3 receptor activity in mediating IMB anorexia in the aminoprivic feeding model. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)487-491
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number3
StatePublished - Mar 1999
Externally publishedYes


  • Amino acid imbalance
  • CCK(A) receptor
  • CCK(B) receptor
  • Devazepide
  • Food intake
  • L-365,260
  • Nutrition
  • Rat
  • Serotonin receptor
  • Tropisetron

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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