Abstract
Serotonin3 (5-HT3) receptors in the periphery mediate anorectic responses to the amino acid deficiency, which occurs after eating amino acid-imbalanced diets (IMB). However, other neurochemical systems, notably cholecystokinin (CCK), are known to affect food intake. We pretreated rats systemically with tropisetron, a 5-HT3 receptor antagonist, alone and combined with antagonists of CCK(A) and CCK(B) receptors, and measured intake of an IMB. Devazepide, a CCK(A) receptor antagonist, appeared to interact with tropisetron in the anorectic responses to IMB, blunting the usual remediation of IMB anorexia by tropisetron. The CCK(B) receptor antagonist, L-365, 260, increased intake of both IMB and an amino acid-balanced basal diet (BAS) and did not interact with tropisetron. Our data suggest that activation of CCK(A) receptors is interactive with 5-HT3 receptor activity in mediating IMB anorexia in the aminoprivic feeding model. Copyright (C) 1999 Elsevier Science Inc.
Original language | English (US) |
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Pages (from-to) | 487-491 |
Number of pages | 5 |
Journal | Pharmacology Biochemistry and Behavior |
Volume | 62 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1999 |
Externally published | Yes |
Keywords
- Amino acid imbalance
- CCK(A) receptor
- CCK(B) receptor
- Devazepide
- Food intake
- L-365,260
- Nutrition
- Rat
- Serotonin receptor
- Tropisetron
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience