Abstract
The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 288-292 |
| Number of pages | 5 |
| Journal | Science |
| Volume | 251 |
| Issue number | 4991 |
| State | Published - Jan 18 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- General