Cavernous malformations: A review and current controversies

James E. Conway, Daniele Rigamonti

Research output: Contribution to journalReview article

Abstract

Cavernous malformations, also known as cavernous angiomas, are a specific type of cerebrovascular anomaly. Cavernous malformations have characteristic pathologic, radiographic, and genetic characteristics. Conservative management, radiation therapy, and surgical resection have been employed in the management of these lesions. In this review, we will discuss various aspects of cavernous malformations. We will present the pathology of the lesion and the differences between normal microvascular architecture and that found in cavernous malformations. We will present the epidemiology, clinical presentation, and natural history of intracranial and spinal cavernous malformations. Radiologic characteristics and the genetic and molecular causes of these lesions will be reviewed. Current treatment strategies will be discussed and controversies will be addressed.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalNeurosurgery Quarterly
Volume16
Issue number1
DOIs
StatePublished - Mar 1 2006

    Fingerprint

Keywords

  • Angioma
  • Cavernous
  • Malformation
  • Vascular

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this