Caveolin-1, caveolae, and glioblastoma

Marie Odile Parat, Gregory J. Riggins

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing, and signaling roles. Caveolin-1 is a membrane protein that participates in the formation of caveolae and binds a multitude of signaling proteins, compartmentalizing them in caveolae and often directly regulating their activity via binding to its scaffolding domain. Caveolin-1 has been proposed to behave either as a tumor suppressor or as an ongogene depending on the tumor type and progress. This review discusses the existing information on the expression and function of caveolin-1 and caveolae in GBM and the role of this organelle and its defining protein on cellular signaling, growth, and invasiveness of GBM. We further analyze the available data suggesting caveolin-1 could be a target in GBM therapy.

Original languageEnglish (US)
Pages (from-to)679-688
Number of pages10
JournalNeuro-oncology
Volume14
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • EGF receptor
  • caveolae
  • caveolin-1
  • glioblastoma
  • uPA

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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